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. 2022 Jan 25;13:501. doi: 10.1038/s41467-022-28158-2

Fig. 7. USP44 promotes the radiosensitivity of NPC cells in vivo.

Fig. 7

The SUNE1 cells stably transfected with indicated plasmids were implanted subcutaneously into female BALB/c nude mice to construct xenograft growth models and exposed to 8Gy IR or not. a–c Macroscopic images (a), average volume (b) and average weight (c) of the excised tumours for each group (n = 10). d, e Representative images of immunohistochemical staining and IHC scores for USP44, TRIM25, Ku80 and caspase 3 expression in the excised tumours from each group (n = 5 for IR+USP44 group and n = 10 for the other three groups). Scale bars, 50 μm. f–h Macroscopic images (f), average volume (g) and average weight (h) of the excised tumours for each group (n = 6). Data in b, c, g, h are presented as the mean ± SEM, and those in e are presented as the mean ± SD; the P values were determined using the two-tailed Student’s t-test. Source data are provided as a Source Data file.