TABLE 3.
Comparison of CSF P-tau measures for global and domain-specific cognitive decline and cortical thickness among individuals with elevated brain amyloid based on amyloid PET
| Global z-score | Memory z-score | Executive function z-score | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CSF Predictor | b(se) | p-value | AIC | b(se) | p-value | AIC | b(se) | p-value | AIC |
|
| |||||||||
| Elecsys P-tau 181 | 0.02 (0.07) | 0.771 | 708.8 | −0.01 (0.08) | 0.863 | 949.6 | −0.02 (0.08) | 0.840 | 1015.0 |
| time | −0.10 (0.02) | <0.0001 | −0.05 (0.02) | 0.007 | −0.13 (0.02) | <0.0001 | |||
| Elecsys P-tau 181*time | −0.04 (0.01) | 0.003 | −0.04 (0.01) | 0.001 | −0.02 (0.01) | 0.163 | |||
| MSD P-tau181 | −0.04 (0.06) | 0.448 | 698.4 | −0.12 (0.06) | 0.059 | 942.4 | −0.01 (0.06) | 0.828 | 1010.3 |
| time | −0.07 (0.02) | <0.001 | −0.02 (0.02) | 0.214 | −0.11 (0.02) | <0.0001 | |||
| MSD P-tau181*time | −0.04 (0.01) | <0.0001 | −0.04 (0.01) | <0.0001 | −0.03 (0.01) | 0.006 | |||
| MSD P-tau217 | −0.07 (0.04) | 0.116 | 687.1 | −0.13 (0.04) | 0.004 | 929.1 | −0.03 (0.05) | 0.533 | 1006.9 |
| time | −0.05 (0.02) | 0.006 | −0.002 (0.02) | 0.898 | −0.09 (0.02) | <0.001 | |||
| MSD P-tau217*time | −0.04 (0.01) | <0.0001 | −0.04 (0.01) | <0.0001 | −0.03 (0.01) | <0.001 | |||
|
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|
| |||||||||
| Visual-spatial z-score | Language z-score | Cortical Thickness z-score | |||||||
| CSF Predictor | b(se) | p-value | AIC | b(se) | p-value | AIC | b(se) | p-value | AIC |
|
| |||||||||
| Elecsys P-tau 181 | 0.05 (0.06) | 0.455 | 888.2 | 0.01 (0.08) | 0.890 | 1027.1 | 0.01 (0.01) | 0.421 | −359.9 |
| time | −0.06 (0.01) | <0.0001 | −0.09 (0.02) | <0.0001 | −0.02 (0.003) | <0.0001 | |||
| Elecsys P-tau 181*time | −0.01 (0.01) | 0.249 | −0.04 (0.01) | 0.006 | −0.005 (0.002) | 0.007 | |||
| MSD P-tau181 | −0.004 (0.05) | 0.932 | 887.4 | −0.04 (0.06) | 0.490 | 1016.1 | −0.002 (0.01) | 0.787 | −363.3 |
| time | −0.05 (0.02) | 0.002 | −0.06 (0.02) | 0.006 | −0.01 (0.003) | <0.0001 | |||
| MSD P-tau181*time | −0.02 (0.01) | 0.060 | −0.05 (0.01) | <0.0001 | −0.005 (0.001) | <0.0001 | |||
| MSD P-tau217 | −0.03 (0.04) | 0.450 | 886.0 | −0.05 (0.04) | 0.294 | 1005.3 | −0.01 (0.01) | 0.166 | −365.2 |
| time | −0.04 (0.02) | 0.012 | −0.03 (0.02) | 0.099 | −0.01 (0.003) | <0.001 | |||
| MSD P-tau217*time | −0.01 (0.01) | 0.019 | −0.05 (0.01) | <0.0001 | −0.004 (0.001) | <0.0001 | |||
Abbreviations: AIC, Akaike Information Criteria; CSF, cerebrospinal fluid; se, standard error; MSD, Mesoscale discovery platform; P-tau181, phosphorylated tau 181; P-tau217, phosphorylated tau 217.
Multivariate models adjust for age, sex, education, and APOE.