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. 2022 Jan 12;12:814241. doi: 10.3389/fphar.2021.814241

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Copyright © 2022 Wen, Jiang, Liang, Cheng, Zhu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The pathways regulated by microRNAs in morphine-mediated apoptosis of macrophages. After morphine treatment, the expression level of miR-338-3p in peritoneal macrophages increased significantly, which decreased the expression level of Sox4, leading to the increase of caspase-3 expression level, and then promoting cell apoptosis. MicroRNA-873 inhibits morphine-induced macrophage apoptosis by increasing the expression of A20. MicroRNA-219-5p inhibits morphine-induced apoptosis by targeting WEE1, the key cell cycle regulator. (“+” represents promotion, and “−” represents inhibition.)