Fig. 3.

Varying the threshold for what to call deleterious mutations. The black line shows AIC score (on the left axis), and the gray line shows the proportion of mutant proteins that is considered deleterious (the right axis). In yeast (A, B, C), the best model uses all mutations, that is, the AIC score of the model using Ψ_del as the explanatory variable decreases the closer Ψ_del gets to Ψ_tot. In Cr, a cutoff of approximately −2 gives Ψ_del the biggest ΔAIC compared with the model using all protein mutants.