Table 3.

ROC curve analysis of the diagnostic ability of MIF, ITGA2, and COL2A1 in the validation phase.

Protein	AUC	95% CI	Sensitivity	Specificity	P-value
MIF	0.701	0.574–0.828	81.3%	53.1%	0.006
ITGA2	0.801	0.691–0.911	84.4%	71.9%	<0.001
COL2A1	0.773	0.660–0.887	81.3%	62.5%	<0.001
MIF and ITGA2 panel	0.829	0.728–0.930	87.5%	75.0%	<0.001
ITGA2 and COL2A1 panel	0.867	0.777–0.958	81.3%	87.5%	<0.001
MIF and COL2A1 panel	0.822	0.720–0.924	84.4%	71.9%	<0.001
Three-protein panel	0.880	0.727–0.962	84.4%	81.2%	<0.001