Table 3.
Prevalence of echocardiographic abnormalities in children and adults with MPS.
| Overall (n = 76) | Children (n = 53) | Adults (n = 23) | p-value | |
|---|---|---|---|---|
| Aortic insufficiency | 32/76 (42%) | 17/53 (32%) | 15/23 (65%) | 0.011* |
| Aortic stenosis | 5/76 (7%) | 2/53 (4%) | 3/23 (13%) | 0.159 |
| Pulmonary insufficiency | 0/76 (0%) | 0/53 (0%) | 1/23 (4%) | 0.303 |
| Pulmonary stenosis | 0/76 (0%) | 0/53 (0%) | 0/23 (0%) | n/a |
| Mitral insufficiency | 50/76 (66%) | 31/53 (59%) | 19/23 (83%) | 0.064 |
| Mitral stenosis | 9/76 (12%) | 3/53 (6%) | 6/23 (26%) | 0.019* |
| Tricuspid insufficiency | 21/76 (28%) | 16/53 (30%) | 5/23 (22%) | 0.580 |
| Tricuspid stenosis | 0/76 (0%) | 0/53 (0%) | 0/23 (0%) | n/a |
| LVM Z score > 2 | 6/76 (8%) | 5/53 (9%) | 1/23 (4%) | 0.661 |
| RWT > 0.41 | 19/76 (25%) | 15/53 (28%) | 4/23 (17%) | 0.395 |
| Concentric remodeling | 16/76 (21%) | 12/53 (16%) | 4/23 (17%) | 0.622 |
| Concentric hypertrophy | 3/76 (4%) | 3/53 (6%) | 0/23 (0%) | |
| Eccentric hypertrophy | 3/76 (4%) | 2/53 (4%) | 1/23 (5%) | |
| LAD Z score > 2 | 20/76 (26%) | 11/53 (21%) | 9/23 (39%) | 0.155 |
| SPAP > 35 mmHg* | 11/40 (28%) | 8/28 (29%) | 3/12 (25%) | 1.000 |
| LVEF <55% | 1/76 (1%) | 0/53 (0%) | 1/23 (5%) | 0.303 |
LAD, Left atrial diameter; LVEF, Left ventricle ejection fraction; LVM, left ventricle mass; RWT, relative wall thickness; SPAP, systolic pulmonary artery pressure. Statistical analysis with Fisher's exact test.
*
p < 0.05.