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. 2022 Jan 12;12:752512. doi: 10.3389/fmicb.2021.752512

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Copyright © 2022 Li, Li, Ni, Zhang, Jia, Wu, Sun and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liver pathological tissue section stained with hematoxylin and eosin and oil red. Red stain indicates adipocytes. (A) HFD; (B) HFDABT; (C) HFDBBR; (D) HFDABTBBR; (E) NCD; (F) NCDBBR. HFD, high fat diet group; HFDBBR, HFD supplemented with berberine; HFDABT, HFD supplemented with antibiotics (by drinking freely); HFDABTBBR, HFD supplemented with berberine and antibiotics; NCD, normal chow diet; and NCDBBR, NCD supplemented with berberine. The upper-right of each histologic photo is a histologic photo with a larger scale.