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. 2022 Jan 31;28(9):857–872. doi: 10.3727/096504021X16203818567367

Figure 2.

Figure 2

c-Src-induced caspase 8 phosphorylation was associated with the mesenchymal phenotype and contributed to chemoresistance in lung adenocarcinoma. (A–C) Immunohistochemical stainings for p-Casp8 (A), E-cadherin (B), and vimentin (C) with high magnification (400×). **p < 0.01. (D) Response to cisplatin plus paclitaxel of patients with resectable lung adenocarcinoma. **p < 0.01. (E) Kaplan–Meier progression-free survival (PFS) curve for 109 lung adenocarcinoma patients with p-Casp8(+) or p-Casp8(−) following two neoadjuvant cycles of cisplatin and paclitaxel.