Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 12;12:813832. doi: 10.3389/fimmu.2021.813832

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Qin, Haynes, D’Souza, Neeson and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Radiotherapy improves the outcomes of CAR-T cells in combination therapy. ①Radiation-induced IFN-γ promotes chemokine secretion of CXCL9/10/11, ②leading to effective CAR-T cell homing to the tumor bed. ③Diminished tumor barriers of cancer-associated fibroblasts (CAF) and extracellular matrix (ECM) promote CAR-T cell infiltration. ④Radiation-induced expression of ICAM-1/VCAM-1 on the endothelium of tumor vasculature facilitated CAR-T cell infiltration. ⑤RT polarized M2 macrophages to M1 macrophages in the TME. ⑥Reduction of TAM and MDSC by RT. ⑦Radiation-induced increased expression of proinflammatory cytokines altered the TME from immunosuppressive “cold” to immune-inflamed “hot”. ⑧Radiation enhanced infiltrated CAR-T cell function with increased expression of TRAIL, IFN-γ and ⑨augmented expansion of CAR-T cells. The figure is created with BioRender.com.