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. 2022 Jan 12;13:807764. doi: 10.3389/fnagi.2021.807764

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Copyright © 2022 Ogonowski, Salcidua, Leon, Chamorro-Veloso, Valls, Avalos, Bisquertt, Rentería, Orellana and Duran-Aniotz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction network of miRNAs-target genes 2. After selecting 86, miRNAs studied in MCI cases were highlighted, all miRNAs (yellow) associated with the modulation of target genes related to AD or other dementias. Interaction network of hub target genes related to AD in blue (GSK3B, BACE1, and IL6), related to dementia in red (NOTCH3, SLC6A3, and GRN), and related to both AD and dementia (APP) in purple experimentally validated by luciferase reporter assay.