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. 2021 Dec 18;121(2):175–182. doi: 10.1016/j.bpj.2021.12.021

Fig. 3.

Fig. 3

Example of a three-state myosin kinetic model. Myosin dimers (red) can transition together between the SRX state and the DRX. Then they can transition independently to a force-generating state. Attachment to actin (blue) and force generation are only allowed if the binding site is available for binding (active state). Rate constants (ki) can be constant or depend on stretch, node force, and/or on the MyBP C status.