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MyBP-C potential roles on thick and thin filaments, and its impact on tension-pCa curves. (A) MyBP-C interaction with the thick and thin filaments. MyBP-C stabilizes the SRX state of myosin dimers. MyBP-C is also able to bind to nearby active binding sites. (B) Tension-pCa curves for the four situations (base, MyBP-C stabilized SRX only, MyBP-C binding only, and MyBP-C stabilized SRX + MyBP-C binding).
