Table 2.

Patient characteristics

	Patient 1	Patient 2	Patient 3
Age at confirmed resistant Herpes Keratitis	68 years	42 years	80 years
Number of prior recurrences	First episode	Second episode	Multiple
Immune status	Azathioprine 100 mg + methylprednisolone 64 mg po for myasthenia gravis exacerbation	Status post HSCT (x2) and chemotherapy for mycosis fungoides (T4N3M0B2). Treatment at diagnosis of HK: methylprednisolone 72 mg po and ruxolitinib 10 mg.	Lymphoma treated with multiple sessions of chemotherapy (R–CHOP, R–CVP) in the past, no current immunosuppressive medication.
Duration of antiviral prophylaxis	Sine	Intermittent Valganciclovir/Acyclovir since 9 years before HK for CMV reactivation, Herpes labialis, Herpes Zoster Ophthalmicus	Acyclovir since 13 years, necessary dosage of 3 × 800 mg to suppress viral activity.
Initial antiviral treatment	Topical Brivudine 5×/d	Acyclovir 5 × 800 mg po	/
Curative antiviral treatment	Topical Ganciclovir 0,15% 8×/d	Topical Foscarnet 1,2% 5×/d	Topical Trifluridine 1% 4×/d + IV Foscarnet
Duration of treatment before corneal scraping	46 days	Immediate upon recurrence shortly after first episode (which required treatment for 11 weeks)	Immediate due to concurrent bacterial ulcer
Total episode duration	64 days	7 weeks	5 weeks