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. 2022 Jan 27;14(1):98–118. doi: 10.4254/wjh.v14.i1.98

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Bile acid secretion and transport from the hepatocyte across the canalicular membrane and enterohepatic circulation: Role of various transporters involved in transport of bile salts and phospholipids across the canalicular membrane. Enterohepatic circulation of bile salts and their regulation via farnesoid X receptor - fibroblast growth factor 15/19 is also depicted. ABCB: ATP-binding cassette subfamily B; FXR: Farnesoid X receptor; FGF: Fibroblast growth factor; FIC1: Familial intrahepatic cholestasis 1; BSEP: Bile salt exporter pump; MDR3: Multidrug-resistant type 3; BA: Bile acids; NTCP: Sodium taurocholate cotransporting polypeptide; OATs: Organic anion transporters.