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. 2022 Jan 15;14(1):242–252. doi: 10.4251/wjgo.v14.i1.242

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Hydrogen, 5-fluorouracil and their combination reduced tumor growth and tumor weight in a murine model of colorectal cancer. A: Tumor size; B: Tumor weight change in mice treated with hydrogen-rich water (HRW), 5-fluorouracil (5-FU) and their combination. P < 0.05 and P < 0.001 compared to control, P < 0.01 compared to 5-FU, P < 0.05 compared to HRW and P < 0.05, P < 0.01 and P < 0.001 compared to combination groups; n = 6 per group. a: P < 0.05 compare to control; b: P < 0.01 compare to control; c: P < 0.001 compare to control; d: P < 0.05 compare to H₂; e: P < 0.01 compare to 5-FU. H₂: Hydrogen; 5-FU: 5-fluorouracil.