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. 2022 Jan 15;14(1):242–252. doi: 10.4251/wjgo.v14.i1.242

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Hydrogen and 5-fluorouracil attenuate fibrosis in tumor tissue of colorectal cancer. A: Trichrome staining of tumor samples revealed that hydrogen (H₂) suppresses fibrosis in the murine model of colorectal cancer (collagen fiber accumulation appears in blue); B: Tumor fibrosis expressed as collagen content (%) in different groups. P < 0.001 compared to control, P < 0.001 compared to 5-fluorouracil, P <0.01 compared to H₂ groups; n = 6 per group. a: P < 0.001 compare to control; b: P < 0.001 compare to 5-FU; c: P < 0.001 compare to H2. H₂: Hydrogen; 5-FU: 5-fluorouracil.