Table 4.
Examples of biomarkers in gastric cancer
|
Genes
|
Purpose
|
Findings
|
Ref.
|
| RUNX3 | Diagnosis/prognosis | Methylation status correlates with liver metastasis | [155] |
| MLH1 | Diagnosis/prognosis | Methylation status correlates with tumor stage | [156] |
| RASSF1A | Diagnosis/prognosis | Methylation status correlates with advanced stage, and lymph node positivity | [157] |
| MGMT | Diagnosis/prognosis | Methylation status correlates with distant metastasis | [156] |
| ANOS1 | Diagnosis | Expression correlates with tumor progression | [158] |
| RPRML | Prognosis | Expression correlates with survival | [159] |
| CTD-2510F5.4 | Diagnosis/prognosis | Expression correlates with clinicopathological classification and survival | [160] |
| lncRNA-GC1 | Diagnosis | Circulating exosomal level correlates with early detection and disease progression | [161] |
| mesothelin | Diagnosis | Expression correlates with Peritoneal Recurrence | [162] |
| MiR-379-5pMiR-410-3p | Prognosis | Expression correlates with metastasis | [163] |
| S100A9 | Diagnosis /Prognosis | Expression correlates with tumor aggressiveness | [164] |
| Notch1/2/3/4 | Prognosis | Expression correlates with immune infiltration | [165] |
| KAT2A | Diagnosis | Expression correlates with depth of tumor invasion and tumor stage | [166] |