Table 1.
Composition and physical characterization of acetylcysteine loaded polymeric mucus penetrating particles.
| Formulation | Drug/Polymer Ratio (w/w) | Water Added | Solvent (DCM) | PVA conc (% w/v) | Sonication time | Mean particle size (nm±SD) | PDI (±SD) | Zeta potential (mV±SD) | Entrapment efficiency (% EE±SD) | Drug loading (% DL ±SD) |
|---|---|---|---|---|---|---|---|---|---|---|
| F1 | 1:05 | 1 ml | 3 ml | 0.25 | 1min | 312.53 ± 20.04 | 0.228 ± 0.06 | −11.5 ± 1.5 | 35.10 ± 2.14 | 3.85 ± 0.35 |
| F1 | 1:10 | 1 ml | 3 ml | 0.25 | 1min | 252.93 ± 13.57 | 0.201 ± 0.06 | −10.2 ± 0.6 | 37.85 ± 0.84 | 5.45 ± 0.08 |
| F1 | 1:15 | 1 ml | 3 ml | 0.25 | 1min | 272.47 ± 9.32 | 0.103 ± 0.07 | −10.7 ± 1.4 | 34.41 ± 0.52 | 2.15 ± 0.03 |
| F2 | 1:05 | 1 ml | 3 ml | 0.50 | 2min | 350.47 ± 45.98 | 0.195 ± 0.10 | −12.6 ± 1.9 | 54.18 ± 1.75 | 5.03 ± 0.29 |
| F2 | 1:10 | 1 ml | 3 ml | 0.50 | 2min | 307.50 ± 9.54 | 0.136 ± 0.02 | −11.3 ± 0.4 | 55.46 ± 2.40 | 9.05 ± 0.22 |
| F2 | 1:15 | 1 ml | 3 ml | 0.50 | 2min | 345.57 ± 6.48 | 0.207 ± 0.06 | −12.1 ± 1.8 | 46.88 ± 0.25 | 2.93 ± 0.01 |
| F3 | 1:05 | 1 ml | 3 ml | 0.75 | 3min | 640.37 ± 18.35 | 0.271 ± 0.02 | −18.9 ± 1.2 | 29.86 ± 1.10 | 2.98 ± 0.18 |
| F3 | 1:10 | 1 ml | 3 ml | 0.75 | 3min | 725.23 ± 8.70 | 0.355 ± 0.03 | −23.4 ± 1.7 | 32.07 ± 0.71 | 4.92 ± 0.06 |
| F3 | 1:15 | 1 ml | 3 ml | 0.75 | 3min | 815.40 ± 20.76 | 0.369 ± 0.01 | −24.8 ± 2.3 | 30.41 ± 0.98 | 1.90 ± 0.06 |
The studies were performed in the triplicate (n = 3).