Figure 6.

Influence of disease activity on chromatin accessibility. (a) MA plots comparing chromatin accessibility in RA patients with low (n=11) versus medium/high CDAI (n=7). Sites with significantly differential accessibility are indicated by red (top more accessible in RA patients with low disease activity). Differential peaks (red) were determined using adjusted (Benjamini and Hochberg) p-value < 0.05. (b) Representative tracks for genes showing differences in accessibility in EM cells of patients with different disease activity. (c) KEGG pathway enrichment for genes associated with sites differentially accessible in EM T cells of patients with different disease activity.