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Model of LBE for lifespan extension and alleviation of toxic protein aggregation. (A) For wild-type worms with short lifespan, LBE shows the longevity effect depending on sir-2.1 and hsf-1 pathway. (B) For wild-type or neurodegenerative worms with hsf-1 deficiency, LBE also extends the lifespan and alleviates toxic protein aggregation in a sir-2.1-dependent manner, possibly through an unknown downstream target. LBE, total water extracts of L. barbarum berry.
