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TME comprising the tumor cells and various stromal cells in GC. They evade immune surveillance during GC progression by balancing energy requirements and in TME. Finally, the metabolites of TME impacts cancer-specific or related phenotypes. Apo E, apolipoprotein E; Ado, adenosine; Oxd, oxidation; PPP, pentose phosphate pathway; ROS, reactive oxygen species; TAM, tumor-associated macrophages.
