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Integration of multimodal and interdisciplinary approaches for big data analysis in irritable bowel syndrome. Created with BioRender.com. ANS: Autonomic nervous system; CNS: Central nervous system; FODMAP: Fermentable oligosaccharides, disaccharides, monosaccharides and polyols; FMT: Fecal microbiota transplant; 5-HT: 5-hydroxytryptamine (serotonin); SCFAs: Short chain fatty acids; GABA: γ-aminobutyric acid; TLRs: Toll-like receptors.
