Figure 6.

Identification of the correlation between BGN and the regulation of immune responses in colon cancer. (A) Volcano plot of the DEGs expression between BGN high and low subgroups. The blue and red dots represented the significantly downregulated and upregulated genes, respectively; The gray dots represented the genes without differential expression. (B, C) GO and KEGG results for differential expression genes. The X-axis represents gene ratio and the Y-axis represents different enriched pathways. (D, E) The enriched gene sets in HALLMARK and C7 collections by samples of DEGs. Each line representing one particular gene set with unique color. Only gene sets with NOM p-value < 0.05 and FDR q-value < 0.05 were considered significant. (F) Heatmap showing BGN-associated GSVA scores of 14 innate and adaptive immunity-related gene sets. (G) Pearson correlation between the GSVA scores of 14 innate and adaptive immunity-related gene sets and the expression level of BGN in colon cancer.