Table 1.
Association between BGN expression and clinicopathological factors of colon cancer patients.
| Variables | Number of cases | Up-regulation of Biglycan numbers (%) | p value | |
|---|---|---|---|---|
| Positive (N=84) | Negative (N=60) | |||
| Gender | ||||
| Male | 99 | 58(69.05%) | 41(68.33%) | 0.927 |
| Female | 45 | 26(30.95%) | 19(31.67%) | |
| Age (years) | ||||
| >=60 | 89 | 53(63.10%) | 36(60.00%) | 0.706 |
| <60 | 55 | 31(36.90%) | 24(40.00%) | |
| Tumor location | ||||
| Colon | 83 | 52(61.90%) | 31(51.67%) | 0.220 |
| Rectum | 61 | 32(38.10%) | 29(48.33%) | |
| Tumor size | ||||
| T1/T2 | 28 | 11(13.10%) | 17(28.33%) | 0.023 |
| T3/T4 | 116 | 73(86.90%) | 43(71.67%) | |
| Lymph node metastasis | ||||
| N0 | 68 | 41(48.81%) | 27(45.00%) | 0.652 |
| N1/N2 | 76 | 43(51.19%) | 33(55.00%) | |
| Distant metastasis | ||||
| M0 | 112 | 62(73.81%) | 50(83.33%) | 0.175 |
| M1 | 32 | 22(26.19%) | 10(16.67%) | |
| length of hospitalization | ||||
| < 10 days | 44 | 20(23.81%) | 24(40.00%) | 0.038 |
| <=10 days | 100 | 64(76.19%) | 36(60.00%) | |
| Tumor type | ||||
| ulcerative | 33 | 18(21.43%) | 15(25.00%) | 0.615 |
| Non-ulcerative | 111 | 66(78.57%) | 45(75.00%) | |
| Tumor differentiation | ||||
| Well to moderate | 128 | 76(92.68%) | 52(89.66%) | 0.528 |
| Poor | 12 | 6(7.32%) | 6(10.34%) | |
| Tumor stage | ||||
| I | 19 | 8(9.52%) | 11(18.33%) | 0.124 |
| II/III/IV | 125 | 76(90.48%) | 49(81.67%) | |
| Disease duration | ||||
| >3 months | 45 | 28(33.73%) | 17(29.31%) | 0.580 |
| <=3 months | 96 | 55(66.27%) | 41(70.69%) | |
| Serosa invasion | ||||
| Yes | 115 | 73(86.90%) | 42(70.00%) | 0.002 |
| No | 29 | 11(13.10%) | 18(30.00%) | |
Length of stay was defined as the number of days the patient was hospitalized for surgical treatment of colon cancer. One day was defined as a hospital stay crossing midnight and was determined by independent physician review from medical records and patient reports. The p value was calculated by the Chi-square test. Bold numbers indicate statistically significant values (p < 0.05).