Table 3.

IC₅₀ values of heterocyclic derivatives against HT29, NCI H1299 and UM-UC3 cell lines.

Entry	Compound	HT29[a] [IC50 in μM]	NCI—H1299[b] [IC50 in μM]	UM-UC3[c] [IC50 in μM]
1	KUNB31 [d]	3.7 ± 0.34	Not tested	3.01 ± 0.56
2	5	18.84 ± 2.6	17.54 ± 0.42	71.63 ± 3.73
3	18	61.95 ± 1.42	> 100	> 100
4	19	> 100	> 100	> 100
5	20	> 100	74.99 ± 21.4	> 100
6	21	93.74 ± 2.67	59.96 ± 10.5	52.95 ± 3.32
7	29 a	63.54 ± 1.69	67.62 ± 4.13	> 100
8	29 b	21.72 ± 2.60	10.02 ± 3.28	55.55 ± 1.34
9	31	59.33 ± 0.18	58.10 ± 0.34	57.4 ± 13.68
10	32 a	51.79 ± 2.18	46.13 ± 1.11	51.3 ± 1.83
11	32 b	47.35 ± 2.94	41.39 ± 1.20	59.4 ± 4.8
12	40	60.25 ± 0.63	59.04 ± 1.78	70.4 ± 0.77
13	41	54.33 ± 1.32	51.31 ± 0.15	51.9 ± 1.27
14	42	58.29 ± 1.51	20.6 ± 0.28	69.9 ± 0.77
15	43	> 100	> 100	> 100
16	44	75.29 ± 0.66	57.76 ± 8.01	59.65 ± 0.21
17	45	Not tested	Not tested	Not tested
18	46	66.52 ± 1.35	68.2 ± 1.20	> 100
19	50	2.33 ± 0.48	1.53 ± 0.16	1.18 ± 0.1
20	51	51.17 ± 2.23	33.73 ± 1.78	51.65 ± 3.32
21	52	51.17 ± 2.23	85.95 ± 7.7	78.25 ± 15.7
22	59 a	51.17 ± 2.23	83.33 ± 1.31	> 100
23	59 b	Not tested	Not tested	Not tested

^[a]colon cancer cell line

^[b]non-small cell lung carcinoma cell line

^[c]bladder cancer cell line.

^[d]KUNB31 IC50 values were taken from Ref. [27].