Fig. 6. (a) Cisplatin(Pt(ii)) activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), which can catalyze the formation of superoxide (O2˙−) and H2O2 from oxygen, iron ions catalyze the Fenton reaction to converse H2O2 into cytotoxic ˙OH. (b) Cisplatin(iv) can be turned into cisplatin(Pt(ii)) by reacting with intracellular GSH. Reproduced with permission from ref. 46. Copyright 2017, American Chemical Society. (c) Schematic illustration of synergistic therapy by combing cisplatin and Fe-based nanomaterials along with consuming the GSH. (d) Schematic illustration of cisplatin-enhanced CDT via adjusting relevant proteins. (e) Schematic illustration of CDT in CDDP-induced anticancer therapy. Reproduced with permission from ref. 47. Copyright 2020, American Chemical Society. (f) Schematic illustration of GSH consumption induced synergistic cisplatin release and ˙OH generation and ˙OH enhanced DNA damage. Reproduced with permission from ref. 48. Copyright 2020, Wiley-VCH.
