Fig. 7. (a) Schematic synthetic process of copper peroxide (CP) nanodots for H2O2 self-supplying enhanced CDT. (b) Fluorescence images of DCFH-DA stained cancer cells (U87MG cell line). Scar bar: 50 μm. (c) CLSM images of acridine orange (AO)-stained cancer cells (U87MG) treated with or without CP nanodots. Scar bar: 20 μm. (d) H&E staining images and (e) TUNEL staining images of tumor slices treated with different groups. Scar bar: 50 μm. Reproduced with permission from ref. 49. Copyright 2019, American Chemical Society. (f) Schematic synthetic process of copper-cysteine mercaptide nanoparticles (Cu-Cys NPs) for copper-involving nanoformulation mediated CDT. (g) GSH/GSSG ratio in cancer cells (MCF-7R) incubated with or without Cu-Cys NPs. (h) Representative photographs of tumors from MCF-7R tumor-bearing mice treated with different groups. Scar bar: 50 μm. Reproduced with permission from ref. 50. Copyright 2019, American Chemical Society.
