Fig. 1.

This figure illustrates the data processing to identify HbA1c pairs for patients in “Titrators” group. To obtain the HbA1c value before OAD titration (pre_HbA1c) and after OAD titration (post_HbA1c) for the analysis, an OAD titration is first identified. In the figure, two OAD titrations (C1 and C2) were identified for the patient (P01). For each OAD titration, the pre_HbA1c is taken to be the most recent HbA1c result within one year before an OAD titration, while the post_HbA1c is the first HbA1c value within twelve weeks to one year after the OAD titration. Abbreviations: C1 = first OAD titration, C2 = second OAD titration, P01 = illustrative patient, pre_HbA1c = HbA1c before OAD titration; post_HbA1c = HbA1c after the OAD titration