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Flow chart illustrating the derivation of the patient cohorts. “No OAD” cohort refers to patients who were not on OAD throughout the study period. “Non-titrators” cohort refers to patients who were on at least one OAD but did not have any OAD dose adjustment during the study period. “Titrators” cohort refers to patients who were on at least one OAD and had at least one OAD dose adjustment during the study period. Abbreviation: n= number of patients, m = number of HbA1c pairs
