Table 3.

Change in HbA1c values (with HbA1c denoted in mmol/mol) after metformin titration

Metformin dose after titration
0	125	250	500	750	850	1000	1500	1700	2000	2250	2550	3000
		-3(-4, -3)#m=487	-7(-7, -7)#m=1849			-10(-11, -9)#m=676	-8(-12, -3)#m=36	-7(-11, -3)#m=60
		-4(-7, -2)#m=34
6(4, 8)#m=173	2(1, 3)#m=105		-4(-6, -4)#m=906			-10(-13, -8)#m=87
6(4, 8)#m=220		3(3, 4)#m=1412		-3(-4, -2)#m=282		-7(-7, -7)#m=3108	-9(-12, -6)#m=77	-14(-18, -11)#m=53
			2(1, 3)#m=182			-3(-4, -2)#m=225	-7(-9, -6)#m=190	-8(-12, -4)#m=31
			3(-0, 6)#m=34			1(-1, 3)#m=58		-3(-6, -2)#m=161			-2(-6, 0)#m=39
8(4, 10)#m=137		8(3, 12)#m=31	6(4, 6)#m=1953	-1(-2, 0)#m=105	-1(-3, 0)#m=57		-4(-6, -5)#m=2150	-7(-7, -6)#m=1670	-4(-7, -3)#m=198		-10(-14, -7)#m=47	-6(-8, -2)#m=47
12(7, 16)#m=41			8(5, 11)#m=96	3(1, 6)#m=91		4(3, 4)#m=1128		-3(-3, -2)#m=739	-4(-6, -3)#m=418	-7(-7, 6)#m=498	-8(-9, -7)#m=398
13(8, 19)#m=46			8(3, 12)#m=38		2(1, 3)#m=240	6(6, 7)#m=773	1(0, 2)#m=142		-2(-3, -2)#m=611		-6(-6, -4)#m=1154
						4(3, 6)#m=228	3(1, 6)#m=82	3(1, 4)#m=127			-3(-4, -2)#m=179	-3(-6, -2)#m=458
						6(2, 9)#m=34	3(3, 4)#m=227	1(-2, 3)#m=30	1(-2, 3)#m=42		-4(-4, -3)#m=311	-4(-7, -2)#m=124
					3(0, 7)#m=30	6(3, 9)#m=75	6(4, 7)#m=165	3(3, 4)#m=920	-1(-2, 0)#m=182	3(-0, 6)#m=33		-3(-4, -2)#m=642
						10(6, 14)#m=41	9(6, 11)#m=65		4(3, 4)#m=438	4(2, 7)#m=35	2(0, 3)#m=129

Change in HbA1c values after metformin initiation, titration, or discontinuation. The values above the diagonal represent the instances where the medication has been initiated or up-titrated, while the values below the diagonal represent instances where the medication has been down-titrated or discontinued. The values refer to the mean difference in HbA1c (MD) and 95% confidence intervals. MD below 0 indicate a lowering in HbA1c while those above 0 indicate an increase in HbA1c. #m refers to the number of HbA1c pairs for that dose titration