Table 6.

Change in HbA1c values (with HbA1c denoted in mmol/mol) after tolbutamide titration

Tolbutamide dose after titration
0	250	500	750	1000	1500	2000	2250	3000
	-8(-11, -6)#m=52	-12(-14, -9)#m=103
6(3, 7)#m=90		-6(-8, -3)#m=92
7(6, 8)#m=177	3(2, 4)#m=243		-3(-7, 0)#m=44	-6(-7, -4)#m=203
		1(-1, 2)#m=89		1(-3, 6)#m=37	-6(-8, -2)#m=52
8(3, 11)#m=45		4(3, 4)#m=277			-3(-6, -2)#m=187
			3(2, 6)#m=64	1(0, 2)#m=190		-1(-4, 2)#m=42	-6(-8, -3)#m=96
				7(3, 11)#m=50				-7(-11, -3)#m=42
					4(3, 6)#m=95			-4(-7, -2)#m=62
					6(2, 9)#m=43	3(2, 6)#m=67

Change in HbA1c values after tolbutamide initiation, titration, or discontinuation. The values above the diagonal represent the instances where the medication has been initiated or up-titrated, while the values below the diagonal represent instances where the medication has been down-titrated or discontinued. The values refer to the mean difference in HbA1c (MD) and 95% confidence intervals. MD below 0 indicate a lowering in HbA1c while those above 0 indicate an increase in HbA1c. #m refers to the number of HbA1c pairs for that dose titration