Table 8.

Change in HbA1c values (with HbA1c denoted in mmol/mol) after linaliptin titration

Linagliptin dose after titration
0	2.5	5
	-9(-11, -7)#m=139	-10(-10, -9)#m=1807
6(2, 9)#m=32		-3(-6, -1)#m=79
7(6, 8)#m=363	2(0, 4)#m=36

Change in HbA1c values after linagliptin initiation, titration, or discontinuation. The values above the diagonal represent the instances where the medication has been initiated or up-titrated, while the values below the diagonal represent instances where the medication has been down-titrated or discontinued. The values refer to the mean difference in HbA1c (MD) and 95% confidence intervals. MD below 0 indicate a lowering in HbA1c while those above 0 indicate an increase in HbA1c. #m refers to the number of HbA1c pairs for that dose titration