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. 2022 Jan 26;41:37. doi: 10.1186/s13046-021-02206-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Comparison of morphological changes in A549 and H1299 cells cultured in hEML-CM and T-CM. a Morphology of A549 cultured in T-CM. b Morphology of A549 cultured in hEML-CM. Images were obtained with a phase-contrast microscope. c Ultrastructure of A549 cultured in T-CM, the cytoplasm contains densely stained lamellar bodies (arrows) inset shows detail of lamellar bodies. d Ultrastructure of A549 cultured in hEML-CM, shows spindled cell with cytoplasmatic filaments (arrows) and dilated rough endoplasmic reticulum (dotted arrow) inset shows detail of like fibronexus structure (asterisk). e Morphology of H1299 cultured in T-CM. f Morphology of H1299 cultured in hEML-CM. Images were obtained with a phase-contrast microscope. g Ultrastructure of H1299 cultured in T-CM, showing cytoplasmatic electron-dense lipid structures (arrows). h Ultrastructure of H1299 cultured in hEML-CM