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. 2022 Jan 26;23:37. doi: 10.1186/s13059-021-02583-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CellPhy tree for the CRC24 and L86 datasets. A “CellPhy-GL” CRC24 tree. Distinct shapes and colors represent cell type: healthy (blue circle); tumor-non-stem from the tumor inferior (TI) region (dark green triangle), tumor-stem from TI region (light green square), tumor-non-stem from the tumor middle (TM) region (dark purple triangle), and tumor-stem from the TM region (light purple square). Only bootstrap support values above 50 are shown. Non-synonymous mutations are displayed on internal branches. B “CellPhy-GL” L86 tree. Distinct shapes and colors represent cell type: healthy diploid cells—from both primary and metastatic sites—(dark purple circle), healthy diploid cells missorted (light purple circle), primary tumor aneuploid cells (light orange square), and metastatic aneuploid cells (dark orange square). Only bootstrap values above 50 are shown