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(A, B) Inhibition of osteoclasts can reduce the ratio of matrix metalloproteinase-13 (MMP-13) positive cells in articular cartilage at 4 weeks after ACLT surgery. Immunostaining and quantitative analysis for MMP-13. (C, D) Immunofluorescence staining and quantitative analysis for collagen X. Scale bar, 50 μm. Means ± SD; **p < 0.01 compared to the the sham group, ##p < 0.01 compared to the the vehicle group
