Table 1.
Effect of pHBSP and infliximab on renal microcirculation in simulated ischemia/reperfusion injury
| Experimental groups | Before ischemia | 5 minutes after | 24 hours after |
|---|---|---|---|
| Sham-operated animals | 898±44y | 900±42y | 881±38y |
| I\R | 904±45y | 219±12x | 430±20x |
| EPO | 899±37y | 637±27xy | 733±31xy |
| pHBSP (5 μg/kg) | 905±44y | 492±21xy | 607±28xy |
| pHBSP (25 μg/kg) | 895±15y | 693±28xy | 771±27xy |
| Infliximab (2 mg/kg) | 900±57y | 249±13x | 448±20x |
| Infliximab (10 mg/kg) | 903±72y | 674±28xy | 743±34xy |
EPO: Ischemia/reperfusion+recombinant erythropoietin, pHBSP: Erythropoietin mimetic peptide, I/R: Ischemia/reperfusion
Note: x – P<0.05, in comparison with the sham-operated animals. y – P<0.05, in comparison with the ischemia/reperfusion group