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. 2022 Jan 6;15:775391. doi: 10.3389/fnins.2021.775391

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Copyright © 2022 Chitramuthu, Campos-García and Bateman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipidomic analyses of NSC-34 cells that stably express hPGRN compared to PGRN knockdown cells showing overall stability of the major lipid classes between the two treatments. (A) There are no differences in quantitatively dominant lipid classes in NSC-34/shPGRN versus NSC-34/hPGRN cells. PGRN depletion is associated with increases in quantitatively minor lipid components including specific members of (B) the Phosphatidic acids (insert showing the structure of Dimyristoyl phosphatidic acid), (C) the ceramides (Cer 34:1, Cer 42:2), and (D) cholesterol esters (CE18:1,CE22:6) (PA, Phosphatidic acids; PC, Glycerophosphocholines; PE, Glycerophosphoethanolamines; PG, Glycerophosphoglycerols; PI, Glycerophosphoinositols; PS, Glycerophosphoserines; SM, Sphingomeylins; Cer, Ceramides; CE, cholesterol esters).