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. 2022 Jan 6;15:775391. doi: 10.3389/fnins.2021.775391

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Copyright © 2022 Chitramuthu, Campos-García and Bateman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PGRN expression levels influence RTK phosphorylation. (A) An RTK phosphotyrosine array shows increased tyrosine phosphorylation of multiple growth factor receptors including RET between NSC-34/shPGRN and NSC-43/hPGRN cells. (B) This was confirmed for RET, by Western blot analysis, while (C,D) in MDA-MD-468 cells PGRN expression increased tyrosine phosphorylation of a different set of receptors including EGFR, ErbB2, Insulin-R, VEGFR3, EphA10 (Exposure time is one minute except for ErbB2, which is approximately 10 min) (p < 0.001-***, p < 0.01-**, Error bars represent s.e.m.).