TABLE 4.
A comparison of membrane proteins identified within the GO term “membrane” with receptor-like properties that are either down regulated or up regulated in shPGRN cells relative to both control cells and PGRN over-expressing cells.
| Down regulated | Up regulated | ||
|
| |||
| Symbol | Gene name | Symbol | Gene name |
| RECEPTOR TYROSINE KINASES | RECEPTOR TYROSINE KINASES | ||
| RET | Ret proto-oncogene (Ret) | AXL | AXL receptor tyrosine kinase (Axl) |
| G-PROTEIN COUPLED | EPHB4 | EPHB4 Epr receptor B4 (Ephb4) | |
| GPR19 | G protein-coupled receptor 19 (Gpr19) | NGFR | Nerve growth factor receptor (Ngfr) |
| GPR85 | G protein-coupled receptor 85 (Gpr85) | PDGFRB | Platelet derived growth factor receptor, beta polypeptide (Pdgfrb) |
| OPRL1 | Opioid receptor-like 1 (Oprl1) | G-PROTEIN COUPLED | |
| PTGER3 | Prostaglandin E receptor 3 (subtype EP3) (Ptger3) | ADRA1D | Adrenenrgic receptor, alpha 1d (adra1d) |
| SSTR2 | Somatostatin receptor 2 (Sstr2) | GPR82 | G protein-coupled receptor 82 (Gpr82) |
| WNT-SIGNALING | GRM1 | Glutamate receptor, metabotropic 1 (Grm1) | |
| Nil | PTGIR | Prostaglandin 1 receptor (IP) (Ptgir) | |
| SEMAPHORIN-SIGNALING | P2RY6 | Pyrimidinergic receptor P2Y, G-protein coupled 6 (P2ry6) | |
| Nil | TSHR | Thyroid stimulating hormone receptor (Tshr) | |
| NOTCH RECEPTORS | WNT-SIGNALING | ||
| Nil | FZD3 | Frizzled class receptor 3 (Fzd3) | |
| IMMUNE RECEPTORS | FZD7 | Frizzled class receptor 7 (Fzd 7) | |
| CD109 | CD109 antigen (Cd109) | LGR6 | Leucine-rich repeat-containing G protein-coupled receptor 6 (Lgr6) |
| CD180 | CD180 antigen (Cd180) | SEMAPHORIN-SIGNALING | |
| CD40 | CD40 antigen (Cd40) | NRP1 | Neuropilin 1 (Nrp1) |
| FCAMR | FC receptor, IgA, IgM, high affinity (Fcamr) | NRP2 | Neuropilin 2 (Nrp2) |
| CSF2RA | Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | PLXNA1 | Plexin A1 (Plxna1) |
| TREML1 | Triggering receptor expressed on myeloid cells-like 1 (Treml1) | NOTCH RECEPTORS | |
| TNFSF8 | Tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) | NOTCH1 | Notch 1 (Notch1) |
| OTHERS | NOTCH4 | Notch 4 (Notch4) | |
| GABRB3 | Gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 (Gabrb3) | IMMUNE RECEPTORS | |
| SORCS3 | Sortilin-related VPS10 domain containing receptor 3 (Sorcs3) | CD200 | CD200 antigen (cd200) |
| VLDLR | Very low density lipoprotein receptor (Vldlr) | NCR1 | Natural cytotoxicity triggering receptor 1 (Ncr1) |
| OTHERS | |||
| RELL1 | RELT-like 1 (Rell1) | ||
| EFNA4 | Ephrin A4 (Efna4) | ||
| FGFRL1 | Fibroblast growth factor receptor-like 1 (Fgfrl1) | ||
| GFRA3 | Glial cell line derived neurotrophic factor family receptor alpha 3 | ||
| IGF2R | Insulin-like growth factor 2 receptor (Igf2r) | ||
| SHH | Sonic hedgehog (Shh) | ||