Table 2.

Hazard ratios and 95% confidence intervals for primary and secondary endpoints according to randomized assignment to vitamin D or placebo

Endpoint	Vitamin D group (n=12 927)	Placebo group (n=12 944)	Hazard ratio (95% CI)	P value
Primary endpoint
Confirmed autoimmune diseases	123	155	0.78 (0.61 to 0.99)	0.05
Secondary endpoints
Confirmed+probable autoimmune diseases	210	247	0.85 (0.70 to 1.02)	0.09
Analyses excluding all prerandomization autoimmune diseases
Confirmed autoimmune diseases	102	128	0.79 (0.61 to 1.03)	0.08
Confirmed+probable autoimmune diseases	170	209	0.81 (0.66 to 1.00)	0.05
Analyses excluding first two years of follow-up
Confirmed autoimmune diseases	54	87	0.61 (0.43 to 0.86)	0.005
Confirmed+probable autoimmune diseases	94	133	0.69 (0.53 to 0.90)	0.007
Individual autoimmune diseases
Confirmed rheumatoid arthritis	15	24	0.58 (0.30 to 1.13)	0.11
Confirmed+probable rheumatoid arthritis	18	27	0.63 (0.34 to 1.15)	0.13
Confirmed polymyalgia rheumatic*	31	43	0.70 (0.44 to 1.12)	0.14
Confirmed+probable polymyalgia rheumatica	32	43	0.72 (0.46 to 1.15)	0.17
Confirmed autoimmune thyroid disease	21	11	1.63 (0.77 to 3.45)	0.20
Confirmed+probable autoimmune thyroid disease	99	94	1.05 (0.78 to 1.41)	0.74
Confirmed psoriasis†	15	23	0.72 (0.37 to 1.39)	0.32
Confirmed+probable psoriasis	17	25	0.70 (0.37 to 1.32)	0.27
Confirmed other autoimmune disease	40	56	0.74 (0.49 to 1.11)	0.15
Confirmed+probable other autoimmune disease	45	63	0.73 (0.50 to 1.08)	0.12

Analyses were from Cox regression models controlled for age, sex, race, and omega 3 fatty acid randomization group.

^*Fourteen participants had confirmed polymyalgia rheumatica without giant cell arteritis, 18 had confirmed giant cell arteritis without polymyalgia rheumatica, and two were confirmed with both.

^†No participants had psoriatic arthritis.