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. 2021 Dec 27;13(12):e20745. doi: 10.7759/cureus.20745

Table 2. Association of hematological parameters in COVID-19 positive ICU versus non-ICU and death versus recovered cases.

AEC, absolute eosinophil count; ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; COVID-19, coronavirus disease 2019; ICU, intensive care unit; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio

Variable Category ICU Non-ICU Test of significance (p-value) Death Recovered Test of significance (p-value
ANC Normal 30 (24.4%) 93 (75.6%) <0.001 10 (8.1%) 113 (91.9%) <0.001
Neutropenia 0 (0%) 5 (100%) 1 (20.0%) 4 (80.0%)
Neutrophilia 67 (54%) 57 (46%) 35 (28.2%) 89 (71.8%)
ALC Normal 46 (30.7%) 104 (69.3%) 0.071 18 (12.0%) 132 (88%) 0.004
Lymphocytosis 2 (33.3%) 4 (66.7%) 0 (0%) 6 (100%)
Lymphopenia 42 (53.2%) 37 (46.8%) 24 (30.4%) 55 (69.6%)
Severe lymphopenia 7 (41.2%) 10 (58.8%) 4 (23.5%) 13 (76.5%)
AEC Normal 87 (43.5%) 114 (56.5%) 0.007 42 (20.9%) 159 (79.1%) 0.031
Eosinophilia 10 (19.6%) 41 (80.4%) 4 (7.8%) 47 (92.2%)
AMC Normal 32 (40.5%) 47 (59.5%) 0.469 15 (19.0%) 64 (81.0%) 0.705
Monocytosis 2 (66.7%) 1 (33.3%) 0 (0%) 3 (100.0%)
Monocytopenia 63 (37.1%) 107 (62.9%) 31 (18.2%) 139 (81.8%)
Platelet count Normal 128 (62.2%) 78 (37.8%) 0.938 38 (18.4%) 168 (81.6%) 0.780
Thrombocytosis 5 (50%) 5 (50%) 1 (10%) 9 (90%)
Thrombocytopenia 22 (61.1%) 14 (38.9%) 7 (19.4%) 29 (80.6%)
D-dimer (226 cases)  Normal  13 (21.7%) 47 (78.3%) <0.001  54 (90.0%) 6 (10.0%) 0.046
Abnormal 75 (45.2%) 91 (54.8%) 130 (78.3%) 36 (21.7%)
Variable Cut-off value ICU Non-ICU Test of significance (p-value) Death Recovered Test of significance (p-value)
NLR  <3.17  10 (14.7%) 58 (85.3%) <0.001  4 (5.9%) 64 (94.1%) 0.002
>3.17 87 (47.3%) 97 (52.7%) 42 (22.8%) 142 (77.2%)
PLR  <150  41 (28.5%) 103 (71.5%) 0.002  20 (13.9%) 124 (86.1%) 0.038
>150 56 (51.9%) 52 (48.1%) 26 (24.1%) 82 (75.9%)
Variable Anemia ICU Non-ICU Test of significance (p-value) Death Recovered Test of significance (p-value)
Male Anemic  43 (37.7%) 71 (62.3%) 0.824  22 (19.3%) 92 (80.7%) 0.332
Normal 26 (39.4%) 40 (60.6%) 9 (13.6%) 57 (86.4%)
Female Anemic 19 (33.9%) 37 (66.1%) 0.106 10 (17.9%) 46 (82.1%) 0.245
Normal  9 (56.2%) 7 (43.8%)  5 (31.2%) 11 (68.8%)