Table 1.

Indications for transfusion in SCD

Indication	Type of transfusion
Acute transfusion indication
Symptomatic anemia: aplastic crisis, acute splenic sequestration	Simple transfusion
Acute clinical stroke or TIA	Exchange transfusion
Acute hepatic sequestration/intrahepatic cholestasis	Simple or exchange transfusion
ACS	Simple or exchange transfusion
Acute multiorgan failure	Simple or exchange transfusion
Preoperative (surgeries lasting > 1 hour and require general anesthesia)	Simple or exchange transfusion
Pregnancy*	Simple or exchange transfusion
Chronic transfusion indication
Primary stroke prevention	Simple or exchange transfusion
Secondary stroke prevention	Simple or exchange transfusion
Recurrent VOC	Simple or exchange transfusion

^* Pregnant women with severe or frequent SCD-related complications or high-risk pregnancy.