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. 2022 Jan 5;11:792584. doi: 10.3389/fcimb.2021.792584

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Copyright © 2022 Caldera-Crespo, Paidas, Roy, Schulman, Kenyon, Daunert and Jayakumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustrates the process of Adenovirus hACE2 mouse model transgenesis as well as clinical symptoms of model after SARS-CoV-2 inoculation. Adv-hACE-2 mice showed greater weight loss, clinical symptoms (interstitial pneumonia, weight loss), and pathology in lung sections in addition to the absence of IFN signaling. Elevated viral RNA levels are seen in lung tissue, but low levels are shown in other tissues (heart, brain, liver spleen) while other tissues are not tropic (kidney, GI, serum). Benefits of this model include the ability to quickly sensitize different species of mice due to the rapid deployability of the adenovirus delivery system for expressing hACE2.