Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 5;11:792584. doi: 10.3389/fcimb.2021.792584

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Caldera-Crespo, Paidas, Roy, Schulman, Kenyon, Daunert and Jayakumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Illustrates the process of Syrian hamster model SARS-CoV-2 inoculation as well as clinical symptoms. Top: Wild-type Hamster ACE-2 are readily susceptible to SARS-CoV-2 infection, particularly nasal olfactory neurons, leading to anosmia. Innate and cell-mediated infiltration were seen at lung with consolidation noted, however no histopathology was seen in extrapulmonary tissues despite viral antigen noted at duodenal and colon epithelia. Bottom: Graph illustrates viral course of SARS-CoV-2 infection in Syrian hamster model. High titers of viral RNA are noted 2 days post-inoculation (DPI), with steady decline of viral load 5 DPI and sharp decline and viral clearance at approximately 7 DPI.