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. 2022 Jan 5;11:792584. doi: 10.3389/fcimb.2021.792584

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Copyright © 2022 Caldera-Crespo, Paidas, Roy, Schulman, Kenyon, Daunert and Jayakumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustrates the process of Ferret model SARS-CoV-2 inoculation and clinical symptoms post-infection. Illustration of SARS-CoV-2 Ferret Direct vs. Indirect transmission experiment. Ferret ACE-2 receptors are readily susceptible to SARS-CoV-2 infection with mild clinical signs seen in in infected ferrets (hyperthermia, mild cough). High titers of viral loads in upper airways provide evidence for direct & indirect contact leading to viral infection though respiratory droplet transmission.