Figure 9.

Illustrates the process of Non-Human Primate model SARS-CoV-2 inoculation and clinical symptoms post-infection. Multiple routes of SARS-CoV-2 inoculation allow researchers to understand which area of the upper airways are most susceptible to SARS-CoV-2 infection, with the highest levels found in the pharynx and nasal cavities. A common NHP model, Rhesus macaques, have been shown to have high levels of viremia & viral loads in feces, with seroconversion comparable to humans and mild clinical symptoms (mild-moderate interstitial pneumonia). No systemic symptoms or ARDS were seen in infected macaques making this model less useful in studying severe COVID-19.