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. 2022 Jan 12;14(1):509–525. doi: 10.18632/aging.203828

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Copyright: © 2022 Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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PAX5 transcriptionally activates and enhances PSMA3-AS1 expression. (A) JASPAR database detected the binding sites of PAX5 and PSMA3-AS1. (B) Knockdown efficiency and amplification efficiency of PAX5 in CCA cells both at mRNA and (C) protein level. (D) PAX5 regulated PSMA3-AS1 expression. (E) The expression of PAX5 in CCA tissues both at mRNA and (F) protein level. (G) PAX5 expression was positively correlated with PSMA3-AS1 expression. (H) The expression of PAX5 in CCA cells both at mRNA and (I) protein level. (J) ChIP assay confirmed that the binding site 1 of PSMA3-AS1 promoter was responsive to PAX5-induced transcription, but no obvious changes in binding site 2. (K) Luciferase reporter assay confirmed that the luciferase activity of the wild type of binding site 1 was increased by elevating PAX5, but no significant change in mutant type group. ^**P < 0.01, ^***P < 0.001.