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. 2022 Jan 4;14(1):253–271. doi: 10.18632/aging.203707

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Copyright: © 2021 Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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LY294002 inhibits OPN-mediated subchondral bone and cartilage degeneration in OA. (A) Western blot analysis of the expression of PTEN, p-AKT and OPN in MC3T3-E1 cells transfected with PTEN-siRNA and treated with LY294002 (10 μM) for 48 h. (B) Representative images and quantitative analysis of p-AKT and OPN co-immunostaining in the tibial subchondral bone in sham group, OA group and LY294002 treatment group. Positive cells were indicated with arrows. Boxed area is magnified in the corner. Scale bars = 50 μm, n = 6.