. 2022 Jan 11;14(1):73–108. doi: 10.18632/aging.203823

Table 3. Correlations between TMPRSS2 and gene markers of diverse types of T cell in TIMER.

Description	Gene markers	LUAD				LUSC
		None		Purity		None		Purity
		P	Cor	P	Cor	P	Cor	P	Cor
Th1	TNF	^***	0.173	^**	0.124	0.9	0.006	0.128	−0.07
	IFNG	0.105	0.072	^*	0.089	^***	0.242	^**	0.149
	TBX21	0.401	−0.037	0.807	−0.011	^***	0.242	^***	0.152
	STAT1	^***	−0.222	^***	−0.211	0.620	0.022	0.329	−0.045
	STAT4	^*	0.101	^**	0.13	^***	0.341	^***	0.249
Th1-like	HAVCR2	0.492	−0.03	0.907	−0.005	^***	0.256	^***	0.153
	IFNG	^***	−0.323	^***	−0.316	0.965	0.002	0.164	−0.064
	CXCR3	0.534	0.027	0.251	0.052	^***	0.272	^***	0.185
	CXCL13	^*	−0.089	0.101	−0.074	^***	0.171	0.131	0.69
	BHLHE40	^***	0.156	^**	0.142	^***	0.301	^***	0.257
	CD4	^***	0.163	^***	0.212	^***	0.35	^***	0.252
Th2	BCL6	^***	0.303	^***	0.304	^***	0.175	^***	0.225
	STAT5A	^***	0.163	^***	0.2	^***	0.359	^***	0.274
	GATA3	0.620	−0.022	0.784	−0.012	^***	0.149	0.073	0.082
	STAT3	^***	0.343	^***	0.353	^***	0.336	^***	0.308
	STAT6	^***	0.372	^***	0.382	^***	0.259	^***	0.264
	IL13	0.0538	0.085	^*	0.095	^***	0.187	^**	0.128
	IL21	^***	−0.149	^***	−0.137	^**	0.142	0.1	0.075
	IL17A	0.0539	−0.085	0.182	−0.06	0.612	−0.023	0.0628	−0.085
Treg	STAT5B	^***	0.237	^***	0.247	0.256	0.051	0.201	0.059
	FOXP3	0.7	0.017	0.310	0.046	^***	0.253	^***	0.151
	TGFB1	^***	0.266	^***	0.291	^**	0.143	0.131	0.069
	CCR8	0.128	0.067	^*	0.096	^***	0.254	^**	0.164
Resting Treg	FOXP3	0.7	0.017	0.310	0.046	^***	0.253	^***	0.151
Resting Treg	IL2RA	^**	−0.141	^**	−0.135	^***	0.206	^*	0.102
Effector Treg T cell	FOXP3	0.7	0.017	0.310	0.046	^***	0.253	^***	0.151
	CTLA4	0.298	−0.046	0.594	−0.024	^***	0.186	0.0992	0.076
	CCR8	0.128	0.067	^*	0.096	^***	0.254	^**	0.164
	TNFRSF9	^*	−0.109	^*	−0.1	^***	0.165	0.193	0.06
Effector T cell	FGFBP2	^***	0.194	^***	0.206	0.0532	−0.086	0.385	−0.04
	FCGR3A	^**	−0.141	^**	−0.122	^***	0.187	0.0722	0.082
	CX3CR1	^***	0.454	^***	0.474	^***	0.342	^***	0.272
Naïve T cell	CCR7	^***	0.233	^***	0.295	^***	0.339	^***	0.26
	SELL	^***	0.152	^***	0.192	^***	0.356	^***	0.262
	TCF7	0.0732	0.079	^*	0.097	^***	0.197	^**	0.136
	LEF1	0.236	0.052	0.195	0.058	^*	−0.1	0.142	−0.067
	PDCD1	^**	−0.126	^*	−0.111	^***	0.214	^**	0.121
	DUSP4	^***	−0.301	^***	−0.296	^***	0.174	^*	0.113
	GZMK	0.843	0.009	0.350	0.042	^***	0.23	^**	0.134
	GZMA	^***	−0.24	^***	−0.234	^*	0.106	0.761	0.014
	IFNG	^***	−0.323	^***	−0.316	0.965	0.002	0.164	−0.064
	CD69	^**	0.133	^***	0.177	^***	0.295	^***	0.198
	ITGAE	^***	−0.199	^***	−0.189	^***	−0.166	^*	−0.117
	CXCR6	0.0849	−0.076	0.254	−0.052	^***	0.22	^**	0.13
	MYADM	^*	0.1	^**	0.117	^***	0.194	^**	0.123
General memory T cell	CCR7	^***	0.233	^***	0.295	^***	0.339	^***	0.26
	SELL	^***	0.152	^***	0.192	^***	0.356	^***	0.262
	IL7R	^**	0.126	^***	0.156	^***	0.255	^***	0.152
Exhausted T cell	HAVCR2	0.492	−0.03	0.907	−0.005	^***	0.256	^***	0.153
	TIGIT	0.209	−0.055	0.494	−0.031	^***	0.221	^**	0.121
	LAG3	^***	−0.211	^***	−0.196	0.0521	0.087	0.947	0.003
	PDCD1	^**	−0.126	^*	0−0.11	^***	0.214	^**	0.121
	CXCL13	^*	−0.089	0.101	−0.074	^***	0.171	0.131	0.069
	LAYN	0.571	0.025	0.387	0.039	0.915	−0.005	0.661	−0.02