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. 2022 Jan 12;12:698166. doi: 10.3389/fphys.2021.698166

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Copyright © 2022 Valentine, Mostafa, Tokuoka, Hamano, Inagaki, Nordin, Motohashi, Kita, Aoki, Shimizu and Shindou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PC alterations in EDL, GAS, and SOL of B10-WT and -mdx mice of various ages (2-, 6-, and 12-week-old) were raised on CE-2 standard chow. EDL (A) and GAS (B) showed similar patterns of mdx-associated PC alterations for increased PC 34:1 and decreased PC 38:6 at ages 6- and 12-weeks, and increased PC 34:2 at age 12-weeks, as well as at age 6-weeks in EDL. Mdx-associated PC alterations in SOL (C) were diminished or absent in several cases. PC peak values are expressed as the percentage of total signals and means ± SD are plotted. Significant variation (p < 0.05) was determined by two-way ANOVA and factor effects for each peak are indicated for age (a), mdx genotype (g), and interactive effects (i). Significant pair-wise differences between same-aged WT and mdx muscles were determined by Sidak’s post-tests; *p < 0.05, ^**p < 0.01. n = 3–6 mice/group. ns; non-significant.